Roxonin (60mg) tablets contain Nimesulide, a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing inflammation, pain, and fever in the body. Nimesulide works by inhibiting cyclooxygenase-2 (COX-2), an enzyme involved in producing prostaglandins. Prostaglandins are chemicals in the body that promote inflammation, pain, and fever. By reducing prostaglandin production, Nimesulide helps to decrease these symptoms.